A general and facile one-pot procedure for the synthesis of 2-substituted pyridines from the corresponding pyridine-N-oxides and nucleophiles is presented as a mild alternative to SNAr chemistry. A variety of nucleophiles and heterocyclic-N-oxides participate effectively in this novel transformation which uses the phosphonium salt, PyBroP, as a means of substrate activation. The discovery, development, and current applications of this reaction are discussed in detail

Synthetic enablement for drug discovery: A new method for the addition of nucleophiles to pyridine-N-oxides

246th National Meeting (2013)

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