The controlled manipulation of the surface of nanoparticles is still a big challenge for the interaction with biological targets such as proteins. Here, we present recent studies of 1) metal oxide nanoparticles (Fe3O4) functionalized with a metal ion coordinating ligand and 2) its interaction with specific targets (i.e. biological macromolecules). The surface of the nanoparticles ranging in size from ~6 nm to ~8 nm was functionalized by short-chain alkoxysilane molecules with a PEG group and amino functional group to 1) make the nanoparticles more soluble in aqueous environment and to 2) further couple with diverse multidentate ligands that we have synthesized for the formation of metal complexes. These functional groups are designed to specifically interact with proteins and other biological macromolecules. These nanoparticles with multiple functionalities can provide sensitivity and binding affinity toward attractive protein targets. Furthermore, the prospect of using the modified nanoparticles for bioanalytical applications, specifically in proteomic analysis, will be discussed.

Functionalized magnetic nanoparticles with multidentate ligands for interaction with proteins

246th National Meeting (2013)

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