Collision-induced dissociation has been known almost as long as mass spectrometry. Thispresentation covers the history of this subject, from early adventitious observations through systematic studies ofthe kinematics and dynamics of inelastic ion/molecule in/surface collisions over a range of collision energies, throughthe development of collision-induced dissociation as a method of characterization of ions to the examination ofindividual constituents of complex mixtures using tandem mass spectrometry. The later development of alternativesto collision-induced dissociation is also mentioned. The talk can be summarized by the acronyms related to themethodology: m*, MIKES, MS/MS, MRM, SID, etc. and alternatively by the people mostly responsible for thesedevelopments �White, Jennings, McLafferty, Futrell, etc.

MS/MS: From Thomson's day to ours

246th National Meeting (2013)

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