An environmentally friendly dehydration strategy for Friedel-Crafts-type (FC) alkylation of unactivated secondary alcohols has been developed. The iron-catalyzed FC using unactivated alcohols allows for reactivity with the intermolecular and intramolecular alkylation of secondary alcohols. Allowing the use of unactivated, secondary alcohols in the FC alkylation reaction provides access to a broader range of substrates than is currently possible with the Friedel-Crafts reaction in an environmentally responsible fashion.Figure 1.  Advances in Friedel-Crafts reactions with secondary alcohols.

Friedel-Crafts-type alkylation of unactivated secondary alcohols

246th National Meeting (2013)

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