New [Au(DACH)2]Cl3 complexes (where DACH = 1,2-Diaminocyclohexane) have been synthesized using trihydrate tetrachloroauric acid HAuCl4�3H2O as gold(III) precursor and different isomeric DACH = 1,2-Diaminocyclohexane as ligands . The synthesized complexes were characterized using elemental analysis, various spectroscopic techniques including UV-Vis, IR spectroscopy, solution and solid-state NMR measurements; and X-ray crystallography. The solid-state 13C NMR chemical shift shows that 1,2-Diaminocyclohexane ligand is strongly bound to the gold(III) center via N donor atoms. An X-ray crystallography reveals that the cyclohexyl ring of DACH attains a chair conformation and the gold(III) coordination sphere adopts a distorted square planar geometry. The potential of new [Au(DACH)2]Cl3 complexes as anticancer agents was investigated by measuring in vitro cytotoxicity and inhibitory effect on human prostate and gastric cancer cell lines. The [Au(trans-DACH)2]Cl3 complex showed better in vitro inhibitory effects against the proliferation of human prostate (PC3) and gastric (SGC7901) cancer cell lines than those of the [Au(cis-DACH)2]Cl3 complex.

New [Au(DACH)<sub>2</sub>]Cl<sub>3 </sub>complexes: Synthesis, characterization, in vitro cytotoxicity and influence of stereochemistry on anticancer activity

247th National Meeting (2014)

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New [Au(DACH)2]Cl3 complexes: Synthesis, characterization, in vitro cytotoxicity and influence of stereochemistry on anticancer activity

New [Au(DACH)₂]Cl₃complexes: Synthesis, characterization, in vitro cytotoxicity and influence of stereochemistry on anticancer activity