Recent progress on metal-catalyzed coupling reactions using N-H ketimine substrates will be discussed. Examples include enantioselective [3+2] cycloaddition to form indenamine derivatives, oxidative or redox neutral [4+2] couplings to form isoquinoline derivatives, hydroaminations with alkynes, and aza-Michael additions. Significant ligand and solvent effects on chemoselectivity and stereoselectivity have been observed. Preliminary results on reaction mechanism studies by stoichiometric transformations for further improvement of catalyst will be presented.

N-H ketimines as building blocks in homogeneous catalysis

247th National Meeting (2014)

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