Visible light photoredox catalysis has recently emerged as a powerful and convenient strategy for the synthesis of organic molecules. We report a photoredox-catalyzed, �-variant of the Mannich reaction, which accomplishes the direct �-aminoalkylation of fully saturated carbonyl compounds. The reaction hinges on the generation of �-enaminyl radical intermediates, which couple with imines to form 1,3-aminoketones. Our proposed mechanistic hypothesis for the �-Mannich reaction is supported by experimental results.

Development of a photoredox-catalyzed �-Mannich reaction

247th National Meeting (2014)

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