The mechanisms of phosphoryl transfer enzymes have garnered considerable attention. Fluoro-containing metal species have been used as transition-state and ground-state analogues in a variety of phosphoryl transfer enzymes and have shed light on the nature of the requirements in the active site to catalyze phosphoryl transfer. Our recent work on �-phosphoglucomutase, phospholipase D, cyclic AMP-dependent protein kinase, and F1-ATPase will be discussed. The relationship of the bonding in transition states and intermediates to the 3-center 4-electron bonding model of stable phosphoranes will be discussed.

Phosphoryl transfer enzymes: Theoretical studies of native enzymes and ground-state and transition-state analogs

247th National Meeting (2014)

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