The copper complex of acetylpyridine methylthiosemicarbazone has been shown to inhibit Topoisomerase IIa enzyme. To test the hypothesis that the palladium(II) and platinum(II) complexes of the same ligand would also inhibit the enzyme due to the same structural geometry (square planar around the metal), a series of acetylpyridine thiosemicarbazone ligands, and their Cu(II) and Pd(II) metal complexes have been synthesized and characterized by NMR. The minimum inhibitory concentrations of each compound was determined with seven different micro-organisms. The results show that the Pd(II) complexes have much the same high anti-proliferative activity as the Cu(II) complexes.

Comparison of a series of 2-acetylpyridine-thiosemicarbazone metal complexes

247th National Meeting (2014)

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