Rhenium(I) tricarbonyl diimine complexes have been established as cytotoxic agents. We have synthesized numerous rhenium(I) diimine pentylcarbonato complexes where the diimines are 2,9-dimethyl, 4,7-dimethyl, 5,6-dimethyl, and 3,4,7,8-tetramethyl- 1,10-phenanthroline complexes. The parent dirhenium decacarbonyl and the corresponding methyl-substituted 1,10-phenanthrolines were refluxed in 1-pentanol in the presence of carbon dioxide to obtain the corresponding pentylcarbonato complexes. The pentylcarbonato complexes have been characterized spectroscopically. The pentylcarbonato complexes containing the diimine ligands 2,9-dimethyl-1,10-phenanthroline and 3,4,7,8-tetramethyl- 1,10-phenanthroline have been characterized through X-ray crystallography. The DNA-binding study of the pentylcarbonato complexes through electronic spectroscopy and electrophoresis reveal that some of these complexes bind the DNA in an intercalative mode.

Synthesis and DNA-binding studies of Re(I)-pentylcarbonato and related complexes

247th National Meeting (2014)

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