Discovered in our laboratory in 2005, the Gadonanotubes (GNTs) are a high-performance MRI contrast agent (CA) material derived from Gd3+-ion clusters encapsulated within ultra-short (20-80 nm) carbon nanotube capsules (see Figure)[1,2].  With T1-weighted relaxivities (r1's) typically = 100 mM-1 s-1/Gd3+ ion, the GNTs are among the highest performing MRI CA materials known. Recent NMRD studies as well as XANES/EXAFS structural investigations will be reported that reveal more about how the GNTs achieve their high-performance characteristics at both low and high magnetic fields. Finally, recent efforts to employ the GNT platform to develop multi-modal imaging agents, as exemplified by the MR/PET agent 64Cu@GNT, will also be presented.[1] B. Sitharaman, et al., �Superparamagnetic Gadonanotubes Are High-performance MRI Contrast Agents,� Chem. Commun. 2005 , 3915-3917.[2] R. Sethi, et al., �The Gadonanotubes Revisited: A New Frontier in MRI Contrast Agent Design,� Inorg. Chim. Acta 2012  , 393, 165-172.

Gadonanotubes: What's new and what's next?

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.