A series of [1,2-a]imidazopyridines were prepared and found to be potent and selective PDE10A inhibitors. Efficacy in both a conditioned avoidance response model (CAR) and novel object recognition model for cognition in rodents demonstrate the promise of this series as a potential therapy for schizophrenia.

Imidazopyridine PDE10 inhibitors

247th National Meeting (2014)

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