Novel small molecule stilbenes with activity against of number of bacterial strains have been synthesized via a transition metal Heck reaction. These compounds exhibit potent activity against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC's as low as 1 �g?/mL. Many of these molecules also exhibit activity against other gram-positive bacteria as well as mycobacterium. These small molecules may also represent a new class of antibiotics and perhaps involve a unique mechanism of action that in the future may help curb the spread of multi-drug resistant bacteria. Design and synthesis of new novel small molecules via the optimized Heck reaction are ongoing and mechanism-of-action studies are currently being initiated by our collaborators.

Design and synthesis of novel small molecule stilbenes with activity against gram-positive bacteria and mycobacterium

247th National Meeting (2014)

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