Type II diabetes mellitus affects millions of people worldwide, and there is an urgent need for novel anti-hyperglycemic drugs to combat this disease. In this project, aryl- C-glycosides have been synthesized via standard cross coupling and carbohydrate chemistry. Their structures were designed based upon known anti-hyperglycemic agents. The target compounds have a carbohydrate moiety linked to an aromatic portion via a short linker, and both the carbohydrate and aromatic portions can be varied to provide a small library of compounds. These compounds will subsequently be evaluated in enzymatic assays as potential anti-hyperglycemic agents for the treatment of Type II diabetes. The results of our experiments to date will be presented. In addition, the challenges and successes of conducting research at a primarily undergraduate institution will be discussed.

Preparation of C-glycosides as potential antihyperglycemic agents at Saginaw Valley State University, a primarily undergraduate institution

247th National Meeting (2014)

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