The water-based layer-by-layer (LbL) assembly method is versatile and can be applied to a broad range of surfaces, making this approach especially appealing for the generation of thin film coatings that can be applied for local delivery of therapeutics. Here we discuss the incorporation of biologic drugs such as growth factors, siRNA, and DNA onto surfaces for a range of applications, including wound remediation and healing. Electrostatically assembled thin films provide a protective environment for these sensitive molecules, while enabling them to be released in a highly controlled fashion from complex substrates ranging from collagen or gelatin sponges to woven wound dressings and microtextured implant surfaces. Depending on the nature of the LbL assembly, we can generate thin films that rapidly release proteins or peptides within minutes for rapid hemostasis, or release growth factors and small molecule therapeutics such as anti-inflammatory drugs for one to several months. Recent work has demonstrated that the introduction of natural, biocompatible and safe nanomaterials that act as diffusion barriers or �gates�, we can modulate the release further, or introduce staged delivery of different therapeutics using these types of materials systems or other simple chemistries to modify the nanolayer systems. We demonstrate efficacy in applications ranging from diabetic ulcer wound treatment to orthopedic implant integration.

Nanolayer approaches to localized delivery:  Short, long and staggered release by design

247th National Meeting (2014)

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