Quinolines and their derivatives have been extensively explored for their biological, anti-filarial, anti-bacterial and anti-malarial activity, and additionally, their cardiovascular, anti-neoplastic and receptor agonist activity. We report the facile synthesis of a novel family of N- PEGylated quinolines by the coupling of PEG 400 with 2-formyl, 3-chloro, 6-amino quinolines via maleic anhydride as an activator. A library of N-PEGylated quinoline derivatives of PEG molecular weights 400 has been prepared rapidly after the activation of PEGs using maleic anhydrides. All compounds were tested for anti-cancer and anti-microbial activity, and the results obtained are discussed herein. Surface passivation of Gold Nanoparticles (AuNP) with PEGylated Quinoline (5a-i ) was accomplished.

Facile polymer supported synthesis of N-PEGylated quinoline scaffolds

247th National Meeting (2014)

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