This paper seeks to contribute to the development of synthetic complexes that mimic the catalytic properties of hydrolysis of metalloenzymes. Metalloenzymes catalyze hydrolytic reactions of various functional groups such as amide bonds (nucleases) and phosphate esters (phosphatases). A large number of these enzymes contain one or more Zn (II) ions at their active centers. [2] In this work we have synthesized and studied the catalytic properties of some Zinc (II) complexes for the hydrolysis of phosphate esters. We studied complexes in order to determine the features of complexes that exhibit high efficiency of catalysis of hydrolysis of phosphate ester bonds. We report the rates of catalysis by these zinc complexes of chelating ligands with nitrogen donors in the hydrolysis of phosphate esters.

Catalysis of hydrolysis of phosphate esters

247th National Meeting (2014)

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