Single-Use Bioreactors are now commonly used for Process Development activities. The advantages of such disposable bioreactor equipment has been well demonstrated over the last years on batch/fed-batch processes. Continuous processes  were  widely applied in the past to increase the overall productivity of small bioreactors or for sensitive molecule production. The process control, contamination risk and complexity  were the main concerns of this operation mode. However, the bioprocessing trends and technology evolution led to reconsidering the perfusion processes. The aim of this presentation is to outline the experimental work and results from a study undertaken to marry the Merck Millipore standard 3 L CellReady single-use bioreactor with the ATF Refine perfusion system and to compare productivity and molecule quality.

Evaluation of single-use bioreactors for perfusion processes

247th National Meeting (2014)

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