Fed-batch process is typically used in biotech industry to produce high yield biopharmaceuticals. To reach the goal, tremendous amount of effort in feed media and feeding strategy development must be spent.  In addition, large facility footprints are also needed to satisfy the manufacturing need. Alternating tangential flow (ATF) does not need complicated feed compositions or large manufacturing facilities, but can produce high yield too. It achieves high titers by retaining and concentrating proteins via media exchange through an external hollow-fiber filters. The waste byproducts are removed and new fresh basal media are replaced. This presentation will focus on a case study to develop high yield bioprocesses for biological protein products with the use of ATF technology.  The comparison with fed-batch in cost of goods and manufacturing needs will also be discussed.

Development of a high yield bioprocess with alternating tangential flow (ATF) technology

247th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.