The development of ROMP-derived oligomeric soluble reagents and scavengers for the application in parallel synthesis are reported. In addition, surface-initiated polymerization from Nb-tagged silica (Nb-Si) and Nb-tagged Cobalt-graphite (Nb-Co/C) magnetic nanoparticles to develop supported reagents and scavengers is also discussed. These reagents are readily synthesized from commercially available starting materials on multi-gram scale with excellent yield and conveniently used in purification-free parallel synthesis. Utilization in benzylation and triazolation reactions with a variety of nucleophiles is reported. Additional uses of oligophosphines, norbornenyl-tagged phosphines (Nb-TPP) and Nb-tagged benzylethyl azodicarboxylate (Nb-BEAD) in variants of the Mitsunobu reaction will also be discussed.

ROMP-derived oligomeric reagents and scavengers: Synthetic application in parallel synthesis

247th National Meeting (2014)

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