Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's and prion disease have certain chemical and biological mechanisms in common, including the aggregation of protein. Some theories postulate that aggregation of the �-Amyloid protein due to misregulation of copper and other metals could play a role in the development of neurodegenerative disorders such as Alzheimer's disease. In addition, metal ion misregulation is often associated with the production of tissue damaging reactive oxygen species. The focus of this project is the synthesis of the hybrid heterocyclic amine LC molecule, which can act as a ligand that can rescue the copper misplaced in amyloid plaques, thus restoring solubility of these aggregates. The compound examined herein is also constructed to quench radical species as a means to reducing neuronal damage associated with Alzheimer's disease as well. Both, biological and chemical experiments are presented in order to analyze the activity of LC in relation to the molecular features associated with this neurodegenerative disorder. These results indicate that the molecule can quench radical species in vitro and in vivo.   Western Blotting, TEM, fluorescence and NMR techniques show that LC is also capable of reversing amyloid fibril formation induced by exposure to copper ions.

Treatment of Alzheimer's disease with bimodal hybrid heterocyclic amine ligands: A closer look into the oxidative pathways and copper misregulation in the disease

247th National Meeting (2014)

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