In the quest for long lasting NO materials the fabrication of a material that relies on an undepleatable NO reservoir is ideal. The use of bioavailable NO resources such as S-nitrosothiols (RSNOs) found circulating in the blood stream present a golden opportunity for access to a renewable source of NO. In order to capitalize on the availability of NO donors the identification of a suitable catalyst which can successfully liberate NO from RSNOs and be incorporated into the polymeric matrix of biomedical devices is imperative. In particular, metal organic frameworks (MOFs) have gained notoriety for their applicability in biomedicine with particular emphasis on their potential as catalysts. In this presentation we explore the reactivity of a Cu2+ based MOF catalyst for NO production from structurally diverse RSNO substrates. The reactivity of the MOF catalyst is determined based on the real-time measurement of NO generated from each substrate and the rate of diffusion for each RSNO substrate through the porous architecture of the MOF catalyst. The ability to attain various NO generation rates is highly desirable for tuning biomaterials with appropriate pharmacokinetic profiles for specific applications, such as blood-contacting or anti-microbial coatings where the critical dosages of NO vary.

Metal organic frameworks for the catalytic generation of nitric oxide from S-nitrosothiols: Insights into reactivity and biomedical device fabrication

247th National Meeting (2014)

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