Hemorrhage accounts for over a third of trauma deaths, over half of these occur before emergency care can be reached.1 Current hemostatic treatments often rely on compression wraps or gauze; however, these treatment options are ineffective for deep wounds that are irregularly shaped. In addition, current dressings do not actively promote clotting and require frequent changes to prevent bacterial and fungal infection. Shape memory polymer (SMP) foams have previously demonstrated exceptional biocompatibility and hemostatic properties in cerebral aneurysms.2 These foams begin to show hemostatic properties within minutes of deployment, which is also promising in the treatment of open wounds with uncontrolled bleeding. Furthermore, the large and rapid expansion of the foam at body temperature is expected to improve treatment by space-filling irregular-shaped wounds. In this study, an antimicrobial hydrogel coating was applied to the SMP foam to enhance fluid uptake and rate. Specifically, a polyurethane SMP foam was coated with a hydrogel based on n-vinylpyrrolidone (NVP) and polyethylene glycol diacrylate (PEGDA). These hemostatic sponges displayed a 20 fold increase in fluid uptake, as compared to uncoated SMP foam. The material design also permits iodine doping to form a similar NVP-Iodine complex as the common surgical scrub, Betadine�. In summary, we have developed the framework to generate rapidly swelling hemostatic sponges with potential antimicrobial and antifungal properties.1Kauvar, David S., Rolf Lefering, and Charles E. Wade. 'Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations.' The Journal of Trauma and Acute Care Surgery60.6 (2006): S3-S11.2Rodriguez JN, Clubb FJ, Wilson TS, Miller MW, Fossum TW, Hartman J,Tuzun E, Singhal P, Maitland DJ. 2013. In vivo response to an implanted shape memory polyurethane foam in a porcine aneurysm model. J Biomed Mater Res Part A 2013:00A:000�000.

Fabrication of hydrogel coated shape memory polymer composites as hemostatic sponges

247th National Meeting (2014)

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