A series of a new type of �N-H� Ni(II) complexes of glycine Schiff Bases will be introduced as well as a study of the general aspects of their reactivity.  Studies into the reactivity of these complexes confirmed that the incorporation of a secondary rather than a tertiary amine into the ligand of these Ni(II) complexes does not interfere with the homologation of the glycine residue.  Therefore, these derivatives are of high synthetic value for the general synthesis of a-amino acids.  Specifically, the utility of these complexes was demonstrated via the asymmetric synthesis of various b-substituted pyroglutamic acids by Michael addition reactions with optically active Michael Acceptors.

Design, synthesis, and application of a series of Ni(II) complexes of glycine derived from metal coordinated secondary amines

247th National Meeting (2014)

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