Synthesis of a series of bis-1,2,3-triazoles containing primary, secondary and tertiary hydroxy groups using copper(I)-catalyzed cycloaddition, �click chemistry�, is reported. Cycloaddition reactions of 1,2-bis(azidomethyl)benzene with various alkynols in the presence of a copper complex catalyst afforded the bis-1,2,3-triazoles. The reactions are performed at ambient temperature and pressure in a solvent-free system, making this method practical, economical and eco-friendly. Characterization by NMR and IR spectroscopy and elemental analysis confirm the identity of the products.

Copper-catalyzed green synthesis of bis-1,2,3-triazoles

247th National Meeting (2014)

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