Most transition metal catalyzed C�H borylations of arenes give regioselectivities that are sterically determined. Nevertheless, directed C�H borylation, where a functional group in the molecule directs functionalization, have been reported. The catalysts with the broadest substrate scope to date have been heterogeneous ones that utilize surface supported phosphine ligands to generate coordinatively unsaturated intermediates that likely have two vacant coordination sites�one for functional group coordination and the other for C�H borylation.Homogenous catalysts that mediate directed C�H borylation have been more limited in scope. This presentation will focus on silyl ligands that possess a pendant donor. These ligands generate catalysts that mediate directed borylations for a number of common directing groups.

Silyl chelating ligands for directed C�H borylation

247th National Meeting (2014)

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