In recent year, the presence of pharmaceutically active compounds in aqueous environment has raised significant concern because of their potential risk to human health and ecosystem. Antibiotics, one of the most frequently prescribed medicines, cannot be completely removed through conventional wastewater treatment process; thus, have been discharged into natural water environment. In all antibiotics, cephalosporins have the second highest usage and have been detected in surface waters in the range of ng/L � �g/L in Taiwan. Oxidative transformation by manganese dioxide (MnO2) was thought to be one of the most important natural attenuation processes for removing organic compounds in aqueous environment since MnO2has strong reduction potential and is abundant in soils and sediments.  Cefazolin was selected as target compound for an in-depth study. The batch experiment was conducted to simulate the oxidative transformation of CFZ by MnO2 performed in aquatic system. The oxidative transformation products of CFZ were investigated and identified. The possible oxidation mechanism of CFZ by MnO2 was also proposed by investigating the kinetics of substructure formation and interaction with MnO2. In addition, the change of toxicity was also evaluated during oxidation process. Results can be used to develop other oxidative transformation fate study of cephalosporin analogues.

Oxidative transformation of cefazolin by manganese dioxide

248th National Meeting (2014)

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