The living cationic ring-opening polymerization of 2-oxazolines has been studied in great detail since its discovery in 1966. The versatility of this living polymerization method allows copolymerization of a variety of 2-oxazoline monomers to give a range of tunable polymer structures and properties, including orthogonal end-group and side-chain modification. However, poly(2-oxazoline)s were almost forgotten in the 1980s and 1990s due to the long reaction times and limited application possibilities. In the new millennium, a revival of poly(2-oxazoline)s has arisen because of their potential use as biomaterials.[1-3]Recent developments that illustrate this potential of poly(2-oxazoline)s will be discussed in this lecture, including their use as pharmaceutical excipients,[4] evaluation of degradation and toxicity behavior[5] as well as the preparation of various side-chain functionalized polymers and their use for the preparation of hydrogel cell scaffolds.[6] REFERENCES [1] R. Hoogenboom, Angew. Chem. Int. Ed. 2009, 48, 7978.[2] O. Sedlacek, B. D. Monnery, S. K. Filippov, R. Hoogenboom, M. Hruby, Macromol. Rapid Commun. 2012, 33, 1648-1662.[3] R. Luxenhofer, Y. Han, A. Schultz, J. Tong, Z. He, Kabanov, R. Jordan, Macromol. Rapid Commun. 2012, 33, 1613-1631.[4] B. Claeys, A. Vervaeck, C. Vervaet, J. P. Remon, R. Hoogenboom, B. G. De Geest, Macromol. Rapid Commun. 2012, 33, 1701.[5] H.P.C. Van Kuringen, J. Lenoir, E. Adriaens, J. Bender, B. G. De Geest, R. Hoogenboom, et al. Macromol. Biosci. 2012, 12, 1114.[6] B. L. Farrugia, K. Kempe, U. S. Schubert, R. Hoogenboom, T. R. Dargaville, Biomacromolecules 2013, 14, 2724; T. Dargaville, B. G. Hollier, A. Shokoomand, R. Hoogenboom, Cell Adhesion and Migration 2014, DOI 10.4161/cam.28205.

Poly(2-oxazoline)s as potent(ial) biomaterials

248th National Meeting (2014)

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