Controlled release drug delivery systems have transformed therapeutics used in modern medicine but exhibit limitations for treating various diseases. Biodegradable polymers have been extensively studied to address such challenges. Through chemically incorporating therapeutic bioactives into a polymer backbone via hydrolytically degradable bonds, high drug loading, improved delivery, and enhanced bioactive stability can be achieved. Polymers containing a non-steroidal anti-inflammatory drug, salicylic acid, and antioxidant molecules from the hydroxycinnamic acid class were synthesized into bioactive-based poly(anhydride-esters) as controlled release drug delivery systems. The synthesis, characterization, drug release profiles, formulation methods, and potential applications of bioactive-containing poly(anhydride-esters) were studied. 

Biodegradable, bioactive-based polymers for controlled release applications

248th National Meeting (2014)

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