Amphiphiles are able to self-assemble into various nanoscale multimolecular assemblies ranging from simple micelles and vesicles to highly organized fibers, helices and tubes. Amphiphilic assembly has gained more and more attention in chemistry, biology, as well as environmental science. Compared with conventional amphiphiles, macrocycle-based amphiphiles have attracted much attention due to their distinctive aggregation behavior. Owing to the reorganized conformation, calixarene-based amphiphiles present a higher tendency to form micelles. However, the molecular recognition of calixarene cavity has almost been ignored to manipulate the assembling behavior of calixarene-based amphiphiles. Herein, we describe a host-guest approach to regulate the assembly of calixarene-based amphiphiles reversibly in virtue of the cavity binding. Scheme 1. Principle of controlled disassembly and reassembly of calixarene-based amphiphile.We thank 973 Program (2011CB932502) and NNSFC (91227107) for financial support.References 1. D.-S. Guo, K. Wang, Y.-X. Wang and Y. Liu, J. Am. Chem. Soc., 2012  , 134, 10244-10250.2. D.-S. Guo, B.-P. Jiang, X. Wang and Y. Liu, Org. Biomol. Chem., 2012  , 10, 720-723.3. Z. Qin, D.-S. Guo, X.-N. Gao and Y. Liu, Soft Matter, DOI: 10.1039/c3sm52866a.

Assembly and disassembly of calixarene-based amphiphiles controlled by molecular recognition

248th National Meeting (2014)

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