The development of multifunctional nanocontainers for imaging, targeting, and drug release is of great importance. Herein, we fabricated multifunctional lipid vesicles with amphiphilic p-sulfonatocalixarenes. Liposomes are the leading drug delivery systems for the systemic (intravenous) administration of drugs and calixarenes are embedded in the bilayer since their amphiphilic nature. The resulting functionalized lipid vesicles exhibited requisite characteristics for drug delivery purposes: (i) a negative charged outer shell resulting from p-sulfonatocalixarenes which leaded to colloidal stabilization, (ii) facile, non-destructive, noncovalent, and modular surface modification using specific host�guest chemistry, (iii) fluorescent properties provided by the non-covalent linkage of a FITC-based dye to the surface, and (iv) surface functionalization with biologically active ligands that enabled specific targeting. The functionalized lipid vesicles could be internalized into targeted cells (MCF7) by receptor-mediated endocytosis. This assembling strategy can be extended to design smart multifunctional materials for biomedical applications.  Scheme 1.  Schematic illustration of lipid vesicles embedded with amphiphilic calixarenes.We thank 973 Program (2011CB932502) and NNSFC (91227107) for financial support.References: 1.    Kim, E.; Kim, D.; Jung, H.; Lee, J.; Paul, S.; Selvapalam, N.; Yang, Y.; Lim, N.; Park, C. G.; Kim, K. Angew. Chem. Int. Ed. 2010 , 49, 4405.2.    Jin, T.; Fujii, F.; Ooi, Y. Sensors 2008 , 8, 6777.

Multifunctional lipid vesicles embedded with amphiphilic calixarenes

248th National Meeting (2014)

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