The development of nanoprobes to interface not only the targeted molecules but also provide responses to external stimuli is increasingly important for point-of-care detection technologies.  We have been investigating functional nanostructures as functional nanoprobes in two related pathways. One involves creation of functional nanoparticles with desired magnetic, electrical, and spectroscopic properties that are dispersed in a solution or assembled on a substrate.  Examples of surface-enhanced Raman scattering detection of biomolecules (e.g., DNAs, miRNAs, proteins, etc.) relevant to medical diagnostics will be discussed.  The other involves creation of electrically-responsive nanoparticle assemblies on a flexible device as sensing arrays.  Examples of flexible chemical sensing of volatile organic compound biomarkers related to detection of human breaths for diagnostics of various diseases will be discussed.  Implications of the findings in these two pathways will also be discussed in terms of translating the technologies to point-of-care detection applications.

Functional nanoprobes and assemblies for detection of biomolecules and biomarkers

248th National Meeting (2014)

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