Trifuoromethylation of aryl C�H bonds are developed using both Pd and Cu catalysts. By designing versatile auxiliaries, a wide range of benzoic acids can be ortho-trifluoromethylated using either the electrophilic Umemoto trifluoromethylating reagents or nucleophiles TMSCF3. The advent of these new catalytic reactions provides rich ground for mechanistic investigations into reactivities of transition metal-CF3 bonds. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/241nm/uploads/69208_ben_equation.jpg' alt='' />

Trifluoromethylation of C�H bonds via Pd or Cu catalysis

248th National Meeting (2014)

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