Since 2005, we have been interested in the development of new difluorocarbene reagents based on non-ozone-depleting-substances (non-ODS). We developed seven reagents in this catagory, including 2-chloro-2,2-difluoroacetophenone (1), chlorodifluoromethyl phenyl sulfone (2), N-tosyl-S-difluoromethyl-S-phenylsulfoximine (3), difluoromethyl(n-butyl)ammonium chloride (4), (chlorodifluoromethyl)trimethylsilane (5), (bromodifluoromethyl)trimethylsilane (6), and (trifluoromethyl)trimethylsilane (7). We will discuss the different reactivity and application scope of these reagents. More recent results in this research topic will be disclosed.

Recent development in difluorocarbene chemistry

248th National Meeting (2014)

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