Recent advances have established alkali-metal magnesiates as novel bimetallic reagents capable of delivering new chemistry irreproducible by either alkali-metal or magnesium reagents on their own. Exhibiting enhanced chemo- and regioselectivities over that of traditional polar organometallic reagents, these multicomponent reagents can participate in many cornerstone organic transformations.Breaking new ground, this talk will report novel applications of this family of cooperative bimetallics in deprotonative metalation reactions as well as in N-heterocyclic cascade activation processes. The first catalytic applications of these compounds will also be discussed focussing on promoting hydroamination of unsaturated organic molecules such as isocyanates and olefins. By trapping and isolating key bimetallic intermediates within these catalytic cycles, we provide mechanistic and structural insights into these ate-catalysed hydroamination processes, revealing the cooperative effects between sodium and magnesium and the role that each metal plays within the transformation involved. Reactions exploiting mixed-metal metalation within carbene (NHC) chemistry and transmetallation processes to transition metal complexes will also be covered.

Alkali-metal magnesiate chemistry: New perceptions and practices in stoichiometric and catalytic applications

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.