Glycosamonoglycans (GAGs) on the cell surfaces play important roles in biological systems. In spite of the importance of GAGs, it is difficult to clarify the key interaction between GAGs and proteins due to the structural complexity and the high molecular weight. Some researchers have been studying the total synthesis of GAGs, but it is still difficult to obtain the synthetic molecules with GAGs functions. We have synthesized sulfated glycopolymer libralies which mimic GAGs structures . The acrylamide derivatives with region selective sulfated GlcNAc were synthesized, and glycopolymers with sulfated GlcNAc were polymerized by radical polymerization. The glycopolymer libraries were evaluated by the inhibition of Alzheimer's disease, where the glycopolymers inhibited the aggregation of Amyloid beta peptides and b-secretase activity. The biological activities depended on the sulfated position of GlcNAc, sugar ratio and molecular weight. The glycopolymers including 6-sulfo-GlcNAc showed the strong activities on inhibition of Alzheimer's disease. We will discuss the activities based on the molecular structure and the multivalent effect.

Glycopolymer with glycosaminoglycan mimic activity

248th National Meeting (2014)

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