This study involved the dissolution of glucosamine hydrochloride tablets and the subsequent measurements for amounts of glucosamine in samples using High Performance Liquid Chromatography (HPLC). Using deaerated water as the dissolution media, 6 tablets, one in each vessel, were run for 45 minutes at 100 revolutions per minute. After 45 minutes samples were taken, filtered and run on an HPLC instrument. The samples were found to contain 83%-108% of the expected value. Filter validation produced a similarly large range indicating poor precision.  Results from a method transfer were not replicable.

Dissolution and HPLC analysis of glucosamine tables: An analytical method transfer that failed

248th National Meeting (2014)

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