By adding a glucose core to enhance the movement of a non-phloem-mobile insecticide to enable moderate phloem mobility, our previous work has verified the mechanisms of plant monosaccharide transporters. However, the insecticidal activity of glucose-insecticide conjugates was evidently reduced. In order to get both satisfactory insecticidal activity and phloem mobility, a series of monosaccharide-chlorfenapyr conjugates was synthesized. Four monosaccharide (glucose, galactose, mannose and xylose) conjugate chlorfenapyr were examined for their effect on uptake. The average mortality of glucose-chlorfenapyr conjugates (GTC) against P. xylostella at the concentration of 50mg L-1 reached 81.5% while the previous work glucose-fipronil conjugates (GTF) against P. xylostella at the concentration of 167mg L-1only about 50%. The cytochrome P450 enzymes of insects were confirmed to have a crucial function to enable high insecticidal activity for monosaccharide-chlorfenapyr conjugates when the conjugates penetrate into the insects. The result of the present work implied that the presence of a monosaccharide core confers phloem mobility to chlorfenapyr and the conjugates were able to get to the pest damage site on plant to release a high insecticidal activity.

Synthesis and insecticidal activity of a series of monosaccharide-chlorfenapyr conjugates and their phloem mobility

248th National Meeting (2014)

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