The root-knot nematode, Meloidogyne incognita, one of the most severe plant-damaging nematodes, causes a great global loss of crops annually. At present, only a few commercial organophosphorous and carbamate nematicides are widely applied for control of plant-parasitic nematodes. Thus, the search for safer, environmentally friendly and high-efficacy nematicides is urgently desired. In our discovery of potential nematicidal agents, 49 novel N-phenylthiazolidine-4-one derivatives were synthesized, and their structures were characterized by 1H NMR, 13C NMR and HRMS. Their nematicidal activities against Meloidogyne incognita were evaluated in a range of 10-40 �g/mL. The results showed that 12 compounds therein inhibited the infection of Meloidogyne incognita effectively at the concentration of 40 �g/mL, with the inhibition rate of up to 100%. When the treatment concentration was reduced to 10 �g/mL, several compounds still maintain the inhibition rate of above 50%. It suggests that N-phenylthiazolidine-4-one derivatives can be regarded as lead structures to find novel nematicides against Meloidogyne incognita.

Synthesis and nematicidal bioactivities of novel <i>N</i>-phenylthiazolidine-4-one derivatives against <i>Meloidogyne incognita</i>

248th National Meeting (2014)

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Synthesis and nematicidal bioactivities of novel N-phenylthiazolidine-4-one derivatives against Meloidogyne incognita