Nine new spirobisnaphthalenes, palmarumycins B1�B9, along with thirteen known compounds, were isolated from cultures of the fungus Berkleasmium sp., an endophyte isolated from the medicinal plant Dioscorea zingiberensis C. H. Wright. The structures of the new compounds were elucidated by analysis of the 1D, 2D NMR and HRESIMS spectra, and by comparison with the known compounds. Several compounds contain an uncommon 2,3-dihydro-1H-inden-1-one unit. All isolated compounds were evaluated for their antibacterial activities against Bacillus subtilis, Staphylococcus haemolyticus, Agrobacterium tumefaciens, Pseudomonas lachrymans, Ralstonia solanacearum, and Xanthomonas vesicatoria, and for their antifungal effects against the spore germination of Magnaporthe oryzae. Palmarumycin C8 exhibited the best antibacterial and antifungal effects. In addition, diepoxin d, and palmarumycin C8 showed pronounced cytotoxic activities against five human cancer cell lines (HCT-8, Bel-7402, BGC-823, A 549, A 2780) with IC50 values of 1.28�5.83 �M.

Bioactive spirobisnaphthalenes from the endophytic fungus <i>Berkleasmium</i> sp.

248th National Meeting (2014)

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Bioactive spirobisnaphthalenes from the endophytic fungus Berkleasmium sp.