Responsive nanoparticles were obtained by growing poly(N-isopropyl acrylamide) ((PNIPAM)) and copolymers derived from poly(ether oxide) monomers (MO2MA, HOEGMA) at different rates by a controlled radical polymerization (ARGET-ATRP) from quantum dots (QDs) surfaces.Each step of the synthesis process was monitored by the combination of different techniques like FT-IR, fluorescence, transmission electron microscopy, etc.  The influence of the polymerization time or monomer rate on the final photophysical properties of the nanomaterials were studied by fluorescence spectroscopy.The temperature responsive behavior of the ZnO/(co-)polymer nanohybrids was studied by Dynamic Light Scattering (DLS) and fluorescence spectroscopy.The drug loading and release capacity and cytotoxicity of poly(ether oxide) derivatives core/shell NPs towards cancer cells were evaluated. Results obtained demonstrate the influence of the co-polymer structure for cancer therapy application.

Non-cytotoxic smart fluorescent core/shell nanoparticles and their application in cancer therapy

248th National Meeting (2014)

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