Although gas chromatography (GC) is widely used in pharmaceutical industry for analysis of volatile components in liquid and solid samples matrices, there is a growing need to monitor gases and gaseous by-products encountered in the production of intermediates and active pharmaceutical ingredients (APIs).  Due to increasing complexity of pharmaceutical production, monitoring reactions that produce or consume gases may be important for initial route development as well as commercial production and quality control.  To address these challenges we have been evaluating an SRI model 8610C gas chromatograph configured for direct gas phase analysis. The instrument is equipped with a heated transfer line and electronically controlled gas sampling valve which allows gaseous samples to be directly introduced for GC analysis.  Analyte detection is conducted by using thermal conductivity and helium ionization detectors.  Both are considered to be universal detectors with complementary  dynamic range and sensitivity.  In addition the SRI-GC instrument is compact and portable, it can be taken directly to the site where analysis is needed.  The current presentation will discuss the model 8610C instrument evaluation and selected examples of gas phase analysis in support of chemistry development conducted in the environmental and process safety lab.

Portable GC for headspace gas analysis in pharmaceutical production

248th National Meeting (2014)

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