The large intestine is vitally important to human health.  Also referred to as the �gut microbiome�, the large intestine contains more than 800 species of bacteria that help harvest energy, synthesize vitamins, and shape the immune system. Though it is critically important for human health and has been implicated in many diseases including obesity, diabetes, colorectal cancer, allergies, autism, and Crohn's disease, the mechanism of metabolic communication between the gut microbiome and its human host is poorly understood.  In this work, proton nuclear magnetic resonance, mass spectrometry, and ion chromatography are used to profile the metabolic signatures of rat portal vein blood and stool water and provide insights into the functional segmentation of the rat colon microbiome. Changes in the metabolic profile in different segments of the colon are anticipated due to metabolism by the gut microbiome as well as transport of metabolites across the endothelium.

Metabolic profiling of the rat gut microbiome

248th National Meeting (2014)

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