We prepared organically modified silica (ORMOSIL) colloidal particles with internal functional groups and microporosity, suitable for the incorporation of modalities for both MRI imaging and cancer treatment by neutron capture therapy using boron-10 and gadolinium-157 nuclei.  These modalities were incorporated by preparing ORMOSIL particles with reactive functional groups throughout the nanoparticle body, followed by their conversion into the metal chelating and boron-containing moieties inside the nanoparticles.  For gadolinium-157 chelation, diethylenetriamine groups were introduced and converted to diethylenetriametetraacetic acid groups by facile alkylation with bromoacetic acid under basic conditions.  To incorporate boron-10, internal vinyl groups were introduced and underwent hydroboration under mild conditions with high degrees of conversion.  Furthermore, pH-sensitive carbamate linkages were incorporated into the particles to render them biodegradable, and nanoparticle porosity was controlled by templating the particles with tannic acid.  This talk will describe in detail the preparation, characterization and properties of the resulting theranostic colloidal particles.

Theranostic anticancer agents based on internally functionalized ORMOSIL nanoparticles

248th National Meeting (2014)

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