Scientific interest is directed to smart nanoscale carriers which are capable to deliver the desired medication to target cells. Here, we present UV-crosslinked polymersome with pH-tunable membrane permeability. In addition, the polymersome surface was decorated with folic acid antennas to enhance the selective cellular uptake of polymersomes into tumor cells. ATRP was used to synthesize three different block copolymers with folate acid end functions or with amines and azides for labeling with fluorescent dyes and mixed polymersomes were achieved by self-assembly. It was shown that up to a concentration of 200 �g/ml none of the polymersome formulations by themselves had an adverse effect on the SBC-2 and HEK 293 cell viabilities. Furthermore, the 20 % FA-antenna PS were taken up by the SBC-2 cells with an about 4-fold higher specificity than by the HEK 293 cells and a target delivery of Dox to the cytoplasm of SBC-2 cells was proven.

Stable and pH-responsive polymersomes decorated with folate-antennas for targeting tumor cells

248th National Meeting (2014)

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