Glycoconjugates that constitute Brucella A and M epitopes have been synthesized as discrete antigens and as an antigen expressing both epitopes. The prospects for these antigens as either a universal or specific reagents to detect and diagnose brucellosis will be illustrated. In addition to the simple conjugation methods employed to directly conjugate oligosaccharides to carrier proteins such as tetanus toxoid and a non-protein carrier such as copovidone used in ELISA, the challenges for synthesis of Candida albicans glycopeptide conjugates will be described.Two thiol analogues of gp120 glycans, their chemical conjugation to a filamentous phage carrier, and the LC-UV-MS methodology developed to characterize the resulting glycoconjugates will also be reported.

Conjugation of oligosaccharids and glycopeptides to protein carriers and phage as micropbial and viral vaccine candidates

248th National Meeting (2014)

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