Glycoconjugation is an important approach to enhancing protein stability that requires careful characterization in order to understand the end results of site-specific behavior. In this case study, we utilize SEC combined with multi-angle light scattering (MALS), UV absorption, and differential refractive index (dRI) detection, to determine the conjugation profile, analyze the impact on aggregation and guide the glycoconjugation process.

Characterizing protein glycoconjugates by SEC-UV-MALS-dRI

248th National Meeting (2014)

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