The growing problem of weed resistance is resulting in increasingly serious crop damage and the loss of important herbicides to the farmer, meaning there is an urgent need to introduce new weed control measures into crops. Currently, weed resistance to herbicidal inhibitors of the HPPD enzyme is rare, meaning that herbicides with this mode of action potentially offer important tools for managing resistant weeds. However, the innate crop selectivity shown by many HPPD inhibitors is insufficient to allow their widespread usage in crops. The problem of crop selectivity can be solved by applying a herbicide safener, which protects the crop but not the weeds from the damaging effects of the herbicide. The talk will disclose how different safeners have been combined with non- or partially selective HPPD inhibiting herbicides to yield new resistance breaking solutions for use in cereals, corn and rice. In addition, we will discuss how current research efforts are being directed towards discovering new structural types of HPPD inhibitor which promise to increase the effectiveness and resistance combatting potential of this interesting herbicidal mode of action.

HPPD herbicide-safener combinations as resistance breaking solutions for 21<sup>st</sup> century agriculture

248th National Meeting (2014)

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HPPD herbicide-safener combinations as resistance breaking solutions for 21st century agriculture

HPPD herbicide-safener combinations as resistance breaking solutions for 21^st century agriculture