New chemical classes with new modes of action for their respective insecticidal spectrum have a high value for the development of a sustainable insecticide portfolio. As a result of our continuous efforts to explore novel chemistries a new class of octopaminergic piercing-sucking insecticides was discovered. Starting from an early screening hit, chemistry soon focused on compounds having a benzyl amine moiety as a common structural pattern. Mass screening along with numerous optimization rounds finally led to the discovery of the aminothiazolines. In the context of improving their overall performance, versatile chemistries were developed for a wide scope of structural variations including various backbone modifications. Synthesis, structure-activity relationship and chemical optimization of insecticidal aminothiazolines and related subtypes will be presented.

Aminothiazolines: Novel chemistry for the control of piercing-sucking pests

248th National Meeting (2014)

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