The octopamine agonists chlordimeform and amitraz are known as insecticides and acaricides. We suspected that aryloxy- alkyl- imidazoles were a similar sub-class acting on octopamine receptors with good insecticidal activity. Though known since early 1970s, aryloxy-alkyl-imidazolines were not fully explored particularly with substituents on the alkyl group.We were interested in exploring the potential of aryloxy-alkyl-imidazolines to further increase the potency and increase the spectrum of activity, mainly against hemipteran pests and spider mites. Several analogues were prepared varying substituents on the aryl ring and also on the internal alkyl group and evaluated as insecticides. This poster will present syntheses of various novel aryloxy alkyl imidazolines 1  and structure activity relationships for their insecticidal activity.

Synthesis and insecticidal activity of aryloxy-alkyl-imidazolines

248th National Meeting (2014)

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